I used to like my job but that hasn't been true for a while now. In the last five years, we've lost work/life balance, saw some of our benefits disappear, had to accept that merit no longer means much when it comes to career advancement, and had to deal with a growing number of incompetent managers. I've had enough of it, and I know many others have as well.
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Good choice. Best to get out before pushed because before they push.
At this stage these is no way back for ISRM or McKesson. The core of the company is gone with no appetite to bring it back or re-build.
Take your career and life into your own hands. Why leave one of the most important parts of your life in the hands of people that don't care.
Move on and don't look back.