I moved before things got ugly, but yes, I am very glad I left. I knew the layoffs were coming, and since I wasn't in the Good Ol' Boys Club, a manager I trusted had quietly informed me (on the d/l) that it was going to be my head among others that will be on the chopping block. After well over a decade of faithful service, I thought that was rather nasty of them so...
I found a new (and much better!) job pretty fast, and handed in my notice before the layoffs began in earnest. I don't think they expected that, since I was told in very vulgar terms that I was leaving a client high and dry by leaving. I told them with a smile that it would no longer be my problem, and that they should have thought of that before lining me up for a layoff. After a lot of angry demands to know how I knew, I informed them that they would have to find that out on their own. Then I got something I never expected - an offer from them to stay, and an offer to beat the new salary by a couple percent. Let's just say they were lying through their teeth, and that if I was dumb enough to accept, they would have quietly canned me in a few months after I would have let my guard down (I've seen it happen before, and wasn't about to get s—ed into that one).
The new gig pays $25k/yr more than I made at Fiserv, and I don't have to deal with Frank, Tom, or the toxic cultures that OFS or OFD inflict on its employees.
I'd say start looking, but don't leave until you have somewhere to go with an offer in hand. Keep it tightly on the down-low - if they even think you're looking, they will immediately start preparing to cut you off and add you to the next layoff (or just concoct a reason to fire you - it happens). Once you hand in your resignation (after you have accepted an offer) do NOT, under any circumstance, accept any counter-offers from them. Once you commit, go. You will thank yourself later. I know I do.